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Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water
[Image: see text] The prebiotic origin of catalyst-controlled peptide synthesis is fundamental to understanding the emergence of life. Building on our recent discovery that thiols catalyze the ligation of amino acids, amides, and peptides with amidonitriles in neutral water, we demonstrate the outco...
Autores principales: | Singh, Jyoti, Whitaker, Daniel, Thoma, Benjamin, Islam, Saidul, Foden, Callum S., Aliev, Abil E., Sheppard, Tom D., Powner, Matthew W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204760/ https://www.ncbi.nlm.nih.gov/pubmed/35640067 http://dx.doi.org/10.1021/jacs.2c03486 |
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