A Small Molecule Stabilizes the Disordered Native State of the Alzheimer’s Aβ Peptide

[Image: see text] The stabilization of native states of proteins is a powerful drug discovery strategy. It is still unclear, however, whether this approach can be applied to intrinsically disordered proteins. Here, we report a small molecule that stabilizes the native state of the Aβ42 peptide, an i...

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Detalles Bibliográficos
Autores principales: Löhr, Thomas, Kohlhoff, Kai, Heller, Gabriella T., Camilloni, Carlo, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204762/
https://www.ncbi.nlm.nih.gov/pubmed/35649268
http://dx.doi.org/10.1021/acschemneuro.2c00116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204762/
https://www.ncbi.nlm.nih.gov/pubmed/35649268
http://dx.doi.org/10.1021/acschemneuro.2c00116

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