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A Small Molecule Stabilizes the Disordered Native State of the Alzheimer’s Aβ Peptide
[Image: see text] The stabilization of native states of proteins is a powerful drug discovery strategy. It is still unclear, however, whether this approach can be applied to intrinsically disordered proteins. Here, we report a small molecule that stabilizes the native state of the Aβ42 peptide, an i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204762/ https://www.ncbi.nlm.nih.gov/pubmed/35649268 http://dx.doi.org/10.1021/acschemneuro.2c00116 |