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Isobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC–MS/MS

[Image: see text] Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed positive charge tag to improve quantitation and throughput for polar carboxylic a...

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Detalles Bibliográficos
Autores principales: Armbruster, Michael R., Grady, Scott F., Arnatt, Christopher K., Edwards, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204807/
https://www.ncbi.nlm.nih.gov/pubmed/35726255
http://dx.doi.org/10.1021/acsmeasuresciau.1c00061