A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice

Recently, targeted protein degradation systems have been developed using the ubiquitin-proteasome system. Here, we established Programmed cell death-1 (PD-1) knockdown mice as a model system for subjecting endogenous mouse proteins to the small molecule-assisted shutoff (SMASh) degron system. SMASh...

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Detalles Bibliográficos
Autores principales: Naruse, Chie, Sugihara, Kazushi, Miyazaki, Tatsuhiko, Pan, Xuchi, Sugiyama, Fumihiro, Asano, Masahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Cancer Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204894/
https://www.ncbi.nlm.nih.gov/pubmed/35734392
http://dx.doi.org/10.1093/narcan/zcac019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204894/
https://www.ncbi.nlm.nih.gov/pubmed/35734392
http://dx.doi.org/10.1093/narcan/zcac019

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