Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells

BACKGROUND: Mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in the retinal pigment epithelium (RPE) have been implicated in the pathogenesis of age-related macular degeneration (AMD). However, a deeper understanding is required to determine the contribution of mitochondrial dysfunctio...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhattacharya, Sujoy, Yin, Jinggang, Huo, Weihong, Chaum, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205099/
https://www.ncbi.nlm.nih.gov/pubmed/35715869
http://dx.doi.org/10.1186/s13287-022-02937-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205099/
https://www.ncbi.nlm.nih.gov/pubmed/35715869
http://dx.doi.org/10.1186/s13287-022-02937-6

Ejemplares similares