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Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells

BACKGROUND: Mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in the retinal pigment epithelium (RPE) have been implicated in the pathogenesis of age-related macular degeneration (AMD). However, a deeper understanding is required to determine the contribution of mitochondrial dysfunctio...

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Detalles Bibliográficos
Autores principales:	Bhattacharya, Sujoy, Yin, Jinggang, Huo, Weihong, Chaum, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205099/ https://www.ncbi.nlm.nih.gov/pubmed/35715869 http://dx.doi.org/10.1186/s13287-022-02937-6

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