Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters

Growing evidence supports a role for deficient Wnt signalling in Alzheimer’s disease (AD). First, the Wnt antagonist DKK1 is elevated in AD brains and is required for amyloid-β-induced synapse loss. Second, LRP6 Wnt co-receptor is required for synapse integrity and three variants of this receptor ar...

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Detalles Bibliográficos
Autores principales: Palomer, Ernest, Martín-Flores, Núria, Jolly, Sarah, Pascual-Vargas, Patricia, Benvegnù, Stefano, Podpolny, Marina, Teo, Samuel, Vaher, Kadi, Saito, Takashi, Saido, Takaomi C., Whiting, Paul, Salinas, Patricia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205772/
https://www.ncbi.nlm.nih.gov/pubmed/35296808
http://dx.doi.org/10.1038/s41380-022-01492-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205772/
https://www.ncbi.nlm.nih.gov/pubmed/35296808
http://dx.doi.org/10.1038/s41380-022-01492-z

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