The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism

Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. Here we show that this cohesin acetylation cycle contr...

Descripción completa

Detalles Bibliográficos
Autores principales: van Ruiten, Marjon S., van Gent, Démi, Sedeño Cacciatore, Ángela, Fauster, Astrid, Willems, Laureen, Hekkelman, Maarten L., Hoekman, Liesbeth, Altelaar, Maarten, Haarhuis, Judith H. I., Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205776/
https://www.ncbi.nlm.nih.gov/pubmed/35710836
http://dx.doi.org/10.1038/s41594-022-00773-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205776/
https://www.ncbi.nlm.nih.gov/pubmed/35710836
http://dx.doi.org/10.1038/s41594-022-00773-z

Ejemplares similares