Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport

The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer’s disease (AD). The exact molecular mechanisms underlying tau toxicity are unclear, but aging is irrefutably the biggest risk factor. This raises the question of how cellular senescence affects the function...

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Detalles Bibliográficos
Autores principales: Conze, Christian, Rierola, Marina, Trushina, Nataliya I., Peters, Michael, Janning, Dennis, Holzer, Max, Heinisch, Jürgen J., Arendt, Thomas, Bakota, Lidia, Brandt, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205779/
https://www.ncbi.nlm.nih.gov/pubmed/35393558
http://dx.doi.org/10.1038/s41380-022-01538-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205779/
https://www.ncbi.nlm.nih.gov/pubmed/35393558
http://dx.doi.org/10.1038/s41380-022-01538-2

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