Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

Proteins including FUS, hnRNPA2, and TDP-43 reversibly aggregate into amyloid-like fibrils through interactions of their low-complexity domains (LCDs). Mutations in LCDs can promote irreversible amyloid aggregation and disease. We introduce a computational approach to identify mutations in LCDs of d...

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Detalles Bibliográficos
Autores principales: Murray, Kevin A., Hughes, Michael P., Hu, Carolyn J., Sawaya, Michael R., Salwinski, Lukasz, Pan, Hope, French, Samuel W., Seidler, Paul M., Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205782/
https://www.ncbi.nlm.nih.gov/pubmed/35637421
http://dx.doi.org/10.1038/s41594-022-00774-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205782/
https://www.ncbi.nlm.nih.gov/pubmed/35637421
http://dx.doi.org/10.1038/s41594-022-00774-y

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