Context-dependent enhancer function revealed by targeted inter-TAD relocation

The expression of some genes depends on large, adjacent regions of the genome that contain multiple enhancers. These regulatory landscapes frequently align with Topologically Associating Domains (TADs), where they integrate the function of multiple similar enhancers to produce a global, TAD-specific...

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Detalles Bibliográficos
Autores principales: Bolt, Christopher Chase, Lopez-Delisle, Lucille, Hintermann, Aurélie, Mascrez, Bénédicte, Rauseo, Antonella, Andrey, Guillaume, Duboule, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205857/
https://www.ncbi.nlm.nih.gov/pubmed/35715427
http://dx.doi.org/10.1038/s41467-022-31241-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205857/
https://www.ncbi.nlm.nih.gov/pubmed/35715427
http://dx.doi.org/10.1038/s41467-022-31241-3

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