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Bifurcation drives the evolution of assembly-line biosynthesis

Reprogramming biosynthetic assembly-lines is a topic of intense interest. This is unsurprising as the scaffolds of most antibiotics in current clinical use are produced by such pathways. The modular nature of assembly-lines provides a direct relationship between the sequence of enzymatic domains and...

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Detalles Bibliográficos
Autores principales: Booth, Thomas J., Bozhüyük, Kenan A. J., Liston, Jonathon D., Batey, Sibyl F. D., Lacey, Ernest, Wilkinson, Barrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205934/
https://www.ncbi.nlm.nih.gov/pubmed/35715397
http://dx.doi.org/10.1038/s41467-022-30950-z