Itch and autophagy-mediated NF-κB activation contributes to inhibition of cathepsin D-induced sensitizing effect on anticancer drugs

Inhibition of cathepsin D (Cat D) sensitizes cancer cells to anticancer drugs via RNF183-mediated downregulation of Bcl-xL expression. Although NF-κB activation is involved in the upregulation of RNF183 expression, the molecular mechanism of NF-κB activation by Cat D inhibition is unknown. We conduc...

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Detalles Bibliográficos
Autores principales: Seo, Seung Un, Woo, Seon Min, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205942/
https://www.ncbi.nlm.nih.gov/pubmed/35715412
http://dx.doi.org/10.1038/s41419-022-05011-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205942/
https://www.ncbi.nlm.nih.gov/pubmed/35715412
http://dx.doi.org/10.1038/s41419-022-05011-4

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