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TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy
Ion fluxes across the inner mitochondrial membrane control mitochondrial volume, energy production, and apoptosis. TMBIM5, a highly conserved protein with homology to putative pH-dependent ion channels, is involved in the maintenance of mitochondrial cristae architecture, ATP production, and apoptos...
Autores principales: | Zhang, Li, Dietsche, Felicia, Seitaj, Bruno, Rojas-Charry, Liliana, Latchman, Nadina, Tomar, Dhanendra, Wüst, Rob CI, Nickel, Alexander, Frauenknecht, Katrin BM, Schoser, Benedikt, Schumann, Sven, Schmeisser, Michael J, vom Berg, Johannes, Buch, Thorsten, Finger, Stefanie, Wenzel, Philip, Maack, Christoph, Elrod, John W, Parys, Jan B, Bultynck, Geert, Methner, Axel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206080/ https://www.ncbi.nlm.nih.gov/pubmed/35715207 http://dx.doi.org/10.26508/lsa.202201478 |
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