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Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer

BACKGROUND: Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute to PCa tumor microenvironment (TME) alterations. Here we performed...

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Detalles Bibliográficos
Autores principales: Heidegger, Isabel, Fotakis, Georgios, Offermann, Anne, Goveia, Jermaine, Daum, Sophia, Salcher, Stefan, Noureen, Asma, Timmer-Bosscha, Hetty, Schäfer, Georg, Walenkamp, Annemiek, Perner, Sven, Beatovic, Aleksandar, Moisse, Matthieu, Plattner, Christina, Krogsdam, Anne, Haybaeck, Johannes, Sopper, Sieghart, Thaler, Stefanie, Keller, Markus A., Klocker, Helmut, Trajanoski, Zlatko, Wolf, Dominik, Pircher, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206324/
https://www.ncbi.nlm.nih.gov/pubmed/35717322
http://dx.doi.org/10.1186/s12943-022-01597-7