An mTOR and DNA-PK dual inhibitor CC-115 hinders non-small cell lung cancer cell growth

Molecularly-targeted agents are still urgently needed for better non-small cell lung cancer (NSCLC) therapy. CC-115 is a potent DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) dual blocker. We evaluated its activity in different human NSCLC cells. In various primary hu...

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Detalles Bibliográficos
Autores principales: Chen, Fagui, Zhao, Huasi, Li, Chenhui, Li, Ping, Zhang, Qichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206683/
https://www.ncbi.nlm.nih.gov/pubmed/35717530
http://dx.doi.org/10.1038/s41420-022-01082-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206683/
https://www.ncbi.nlm.nih.gov/pubmed/35717530
http://dx.doi.org/10.1038/s41420-022-01082-6

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