Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application

EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours...

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Autores principales: Marei, Hany E., Althani, Asmaa, Afifi, Nahla, Hasan, Anwarul, Caceci, Thomas, Cifola, Ingrid, Caratelli, Sara, Sconocchia, Giuseppe, D’Agnano, Igea, Cenciarelli, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206693/
https://www.ncbi.nlm.nih.gov/pubmed/35716231
http://dx.doi.org/10.1007/s12672-022-00514-0
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author Marei, Hany E.
Althani, Asmaa
Afifi, Nahla
Hasan, Anwarul
Caceci, Thomas
Cifola, Ingrid
Caratelli, Sara
Sconocchia, Giuseppe
D’Agnano, Igea
Cenciarelli, Carlo
author_facet Marei, Hany E.
Althani, Asmaa
Afifi, Nahla
Hasan, Anwarul
Caceci, Thomas
Cifola, Ingrid
Caratelli, Sara
Sconocchia, Giuseppe
D’Agnano, Igea
Cenciarelli, Carlo
author_sort Marei, Hany E.
collection PubMed
description EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Glioblastoma multiforme (GBM) is a kind of grade IV glioma that has a very dismal prognosis despite advancements in diagnostic methods and therapeutic options. The authors discuss advances in understanding the function of extracellular vesicles (EVs), in overall glioma growth, as well as how recent research is uncovering the utility of EVs in glioma diagnostics, prognostic and therapeutics approaches.
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spelling pubmed-92066932022-06-20 Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application Marei, Hany E. Althani, Asmaa Afifi, Nahla Hasan, Anwarul Caceci, Thomas Cifola, Ingrid Caratelli, Sara Sconocchia, Giuseppe D’Agnano, Igea Cenciarelli, Carlo Discov Oncol Review EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Glioblastoma multiforme (GBM) is a kind of grade IV glioma that has a very dismal prognosis despite advancements in diagnostic methods and therapeutic options. The authors discuss advances in understanding the function of extracellular vesicles (EVs), in overall glioma growth, as well as how recent research is uncovering the utility of EVs in glioma diagnostics, prognostic and therapeutics approaches. Springer US 2022-06-18 /pmc/articles/PMC9206693/ /pubmed/35716231 http://dx.doi.org/10.1007/s12672-022-00514-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Marei, Hany E.
Althani, Asmaa
Afifi, Nahla
Hasan, Anwarul
Caceci, Thomas
Cifola, Ingrid
Caratelli, Sara
Sconocchia, Giuseppe
D’Agnano, Igea
Cenciarelli, Carlo
Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
title Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
title_full Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
title_fullStr Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
title_full_unstemmed Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
title_short Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
title_sort glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206693/
https://www.ncbi.nlm.nih.gov/pubmed/35716231
http://dx.doi.org/10.1007/s12672-022-00514-0
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