PhoP- and GlnR-mediated regulation of metK transcription and its impact upon S-adenosyl-methionine biosynthesis in Saccharopolyspora erythraea

BACKGROUND: Erythromycin A (Er A) has a broad antibacterial effect and is a source of erythromycin derivatives. Methylation of erythromycin C (Er C), catalyzed by S-adenosyl-methionine (SAM)-dependent O-methyltransferase EryG, is the key final step in Er A biosynthesis. Er A biosynthesis, including...

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Detalles Bibliográficos
Autores principales: Pei, Jin-Feng, Li, Yu-Xin, Tang, Hao, Wei, Wenping, Ye, Bang-Ce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206729/
https://www.ncbi.nlm.nih.gov/pubmed/35717184
http://dx.doi.org/10.1186/s12934-022-01846-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206729/
https://www.ncbi.nlm.nih.gov/pubmed/35717184
http://dx.doi.org/10.1186/s12934-022-01846-w

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