Mitochonic Acid-5 Inhibits Reactive Oxygen Species Production and Improves Human Chondrocyte Survival by Upregulating SIRT3-Mediated, Parkin-dependent Mitophagy

Mitochondrial dysfunction is related to the pathogenesis of osteoarthritis (OA); however, there are no effective drugs to treat OA for maintaining mitochondrial homeostasis. Studies have shown that mitochonic acid-5 (MA-5) has a protective effect against mitochondrial damage and plays a role in mito...

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Detalles Bibliográficos
Autores principales: Xin, Ruobing, Xu, Yiyang, Long, Dianbo, Mao, Guping, Liao, Hongyi, Zhang, Ziji, Kang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207248/
https://www.ncbi.nlm.nih.gov/pubmed/35734404
http://dx.doi.org/10.3389/fphar.2022.911716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207248/
https://www.ncbi.nlm.nih.gov/pubmed/35734404
http://dx.doi.org/10.3389/fphar.2022.911716

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