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mRNA and tRNA modification states influence ribosome speed and frame maintenance during poly(lysine) peptide synthesis

Ribosome speed is dictated by multiple factors including substrate availability, cellular conditions, and product (peptide) formation. Translation slows during the synthesis of cationic peptide sequences, potentially influencing the expression of thousands of proteins. Available evidence suggests th...

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Detalles Bibliográficos
Autores principales: Smith, Tyler J., Tardu, Mehmet, Khatri, Hem Raj, Koutmou, Kristin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207662/
https://www.ncbi.nlm.nih.gov/pubmed/35595100
http://dx.doi.org/10.1016/j.jbc.2022.102039