Hydride Transfer Mechanism of Enzymatic Sugar Nucleotide C2 Epimerization Probed with a Loose-Fit CDP-Glucose Substrate

[Image: see text] Transient oxidation–reduction through hydride transfer with tightly bound NAD coenzyme is used by a large class of sugar nucleotide epimerases to promote configurational inversion of carbon stereocenters in carbohydrate substrates. A requirement for the epimerases to coordinate hyd...

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Detalles Bibliográficos
Autores principales: Rapp, Christian, Nidetzky, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207888/
https://www.ncbi.nlm.nih.gov/pubmed/35747200
http://dx.doi.org/10.1021/acscatal.2c00257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207888/
https://www.ncbi.nlm.nih.gov/pubmed/35747200
http://dx.doi.org/10.1021/acscatal.2c00257

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