An analysis of proteogenomics and how and when transcriptome-informed reduction of protein databases can enhance eukaryotic proteomics

BACKGROUND: Proteogenomics aims to identify variant or unknown proteins in bottom-up proteomics, by searching transcriptome- or genome-derived custom protein databases. However, empirical observations reveal that these large proteogenomic databases produce lower-sensitivity peptide identifications....

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Detalles Bibliográficos
Autores principales: Fancello, Laura, Burger, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208142/
https://www.ncbi.nlm.nih.gov/pubmed/35725496
http://dx.doi.org/10.1186/s13059-022-02701-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208142/
https://www.ncbi.nlm.nih.gov/pubmed/35725496
http://dx.doi.org/10.1186/s13059-022-02701-2

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