309 MYC Inhibition Overcomes IMiD Resistance in Heterogeneous Multiple Myeloma Populations

OBJECTIVES/GOALS: Immunomodulatory drugs (IMiDs) are critical to multiple myeloma (MM) disease control. IMiDs act by inducing Cereblon-dependent degradation of IKZF1 and IKZF3, which leads to IRF4 and MYC downregulation (collectively termed the “Ikaros axis”). We therefore hypothesized that IMiD tre...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Lorraine, Walker, Zachary J., Ohlstrom, Denis, Stevens, Brett M., Forsberg, Peter A., Mark, Tomer M., Jordan, Craig T., Sherbenou, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Valued Approaches
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209119/
http://dx.doi.org/10.1017/cts.2022.169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209119/
http://dx.doi.org/10.1017/cts.2022.169

Ejemplares similares