442 Repurposing FDA-approved PI3K/Akt Inhibitors to Improve Anti-Cancer Drug Brain Uptake in Glioblastoma Resection Models

OBJECTIVES/GOALS: We have shown that glioblastoma upregulates blood-brain barrier drug efflux transporters via a mechanism that likely involves TNFα and PI3K/Akt. Our goal is to repurpose FDA-approved PI3K/Akt inhibitors to increase anticancer drug brain concentrations, which holds the potential fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodgers, Louis, Tega, Yuma, Schulz, Julia A., Hartz, Anika M.S., Bauer, Bjoern
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Valued Approaches
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209188/
http://dx.doi.org/10.1017/cts.2022.258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209188/
http://dx.doi.org/10.1017/cts.2022.258

Ejemplares similares