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442 Repurposing FDA-approved PI3K/Akt Inhibitors to Improve Anti-Cancer Drug Brain Uptake in Glioblastoma Resection Models

OBJECTIVES/GOALS: We have shown that glioblastoma upregulates blood-brain barrier drug efflux transporters via a mechanism that likely involves TNFÎ± and PI3K/Akt. Our goal is to repurpose FDA-approved PI3K/Akt inhibitors to increase anticancer drug brain concentrations, which holds the potential fo...

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Detalles Bibliográficos
Autores principales:	Rodgers, Louis, Tega, Yuma, Schulz, Julia A., Hartz, Anika M.S., Bauer, Bjoern
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2022
Materias:	Valued Approaches
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209188/ http://dx.doi.org/10.1017/cts.2022.258

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