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401 Eliminating System xc- Signaling Between Astrocytes and Neurons Selectively Impairs Complex Cognition

OBJECTIVES/GOALS: We aim to determine whether non-neuronal, non-synaptic glutamate signaling mechanisms can be targeted to produce highly specific, narrow changes in brain function that would benefit CNS disorders. To do this, we investigated cognitive changes produced through manipulating the activ...

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Detalles Bibliográficos
Autores principales: Simand, Gregory, Simand, Gregory J., Hess, Evan, Kong, Linghai, Raddatz, Nicholas J., Hurley, Matthew M, Maunze, Brian, Choi, SuJean, Geurts, Aron M., Baker, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209198/
http://dx.doi.org/10.1017/cts.2022.229