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302 Abaloparatide as a novel therapy for posttraumatic osteoarthritis

OBJECTIVES/GOALS: Osteoarthritis (OA) is a cartilage destroying disease. We are investigating abaloparatide (ABL) activation of parathyroid hormone receptor type 1 (PTH1R), which is expressed by articular chondrocytes in OA. We propose ABL treatment is chondroprotective in murine PTOA via stimulatio...

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Detalles Bibliográficos
Autores principales: Landgrave, Samantha H., Ishii, Toru, Maynard, Robert, Wu, Andrew, Godfrey, Dana, Manes, Terrin, Butler, Veronica, Villani, David, Hendesi, Honey, Frank, Rachel, Iyer, Srividhya, Payne, Karin, Adams, Douglas J., Favazzo, Lacey, Lanske, Beate, Zuscik, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209282/
http://dx.doi.org/10.1017/cts.2022.166