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Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62

Autophagy is a housekeeping mechanism tasked with eliminating misfolded proteins and damaged organelles to maintain cellular homeostasis. Autophagy deficiency results in increased oxidative stress, DNA damage and chronic cellular injury. Among the core genes in the autophagy machinery, ATG7 is requi...

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Detalles Bibliográficos
Autores principales: Greer, Stephanie U., Chen, Jiamin, Ogmundsdottir, Margret H., Ayala, Carlos, Lau, Billy T., Delacruz, Richard Glenn C., Sandoval, Imelda T., Kristjansdottir, Sigrun, Jones, David A., Haslem, Derrick S., Romero, Robin, Fulde, Gail, Bell, John M., Jonasson, Jon G., Steingrimsson, Eirikur, Ji, Hanlee P., Nadauld, Lincoln D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209431/
https://www.ncbi.nlm.nih.gov/pubmed/35725745
http://dx.doi.org/10.1038/s41598-022-13569-4