Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities

The success of deep brain stimulation (DBS) therapy indicates that Parkinson’s disease is a brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by DBS remain to be established. We found that augmentation of α rhythms and α coherence between the motor cortex (MC) and...

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Autores principales: Lee, Lan-Hsin Nancy, Huang, Chen-Syuan, Wang, Ren-Wei, Lai, Hsing-Jung, Chung, Chih-Ching, Yang, Ya-Chin, Kuo, Chung-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209473/
https://www.ncbi.nlm.nih.gov/pubmed/35725730
http://dx.doi.org/10.1038/s41531-022-00343-6
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author Lee, Lan-Hsin Nancy
Huang, Chen-Syuan
Wang, Ren-Wei
Lai, Hsing-Jung
Chung, Chih-Ching
Yang, Ya-Chin
Kuo, Chung-Chin
author_facet Lee, Lan-Hsin Nancy
Huang, Chen-Syuan
Wang, Ren-Wei
Lai, Hsing-Jung
Chung, Chih-Ching
Yang, Ya-Chin
Kuo, Chung-Chin
author_sort Lee, Lan-Hsin Nancy
collection PubMed
description The success of deep brain stimulation (DBS) therapy indicates that Parkinson’s disease is a brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by DBS remain to be established. We found that augmentation of α rhythms and α coherence between the motor cortex (MC) and the subthalamic nucleus (STN) is characteristically prokinetic and is decreased in parkinsonian rats. In multi-unit recordings, movement is normally associated with increased changes in spatiotemporal activities rather than overall spike rates in MC. In parkinsonian rats, MC shows higher spike rates at rest but less spatiotemporal activity changes upon movement, and STN burst discharges are more prevalent, longer lasting, and less responsive to MC inputs. DBS at STN rectifies the foregoing pathological MC-STN oscillations and consequently locomotor deficits, yet overstimulation may cause behavioral restlessness. These results indicate that delicate electrophysiological considerations at both cortical and subcortical levels should be exercised for optimal DBS therapy.
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spelling pubmed-92094732022-06-22 Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities Lee, Lan-Hsin Nancy Huang, Chen-Syuan Wang, Ren-Wei Lai, Hsing-Jung Chung, Chih-Ching Yang, Ya-Chin Kuo, Chung-Chin NPJ Parkinsons Dis Article The success of deep brain stimulation (DBS) therapy indicates that Parkinson’s disease is a brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by DBS remain to be established. We found that augmentation of α rhythms and α coherence between the motor cortex (MC) and the subthalamic nucleus (STN) is characteristically prokinetic and is decreased in parkinsonian rats. In multi-unit recordings, movement is normally associated with increased changes in spatiotemporal activities rather than overall spike rates in MC. In parkinsonian rats, MC shows higher spike rates at rest but less spatiotemporal activity changes upon movement, and STN burst discharges are more prevalent, longer lasting, and less responsive to MC inputs. DBS at STN rectifies the foregoing pathological MC-STN oscillations and consequently locomotor deficits, yet overstimulation may cause behavioral restlessness. These results indicate that delicate electrophysiological considerations at both cortical and subcortical levels should be exercised for optimal DBS therapy. Nature Publishing Group UK 2022-06-20 /pmc/articles/PMC9209473/ /pubmed/35725730 http://dx.doi.org/10.1038/s41531-022-00343-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lee, Lan-Hsin Nancy
Huang, Chen-Syuan
Wang, Ren-Wei
Lai, Hsing-Jung
Chung, Chih-Ching
Yang, Ya-Chin
Kuo, Chung-Chin
Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
title Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
title_full Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
title_fullStr Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
title_full_unstemmed Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
title_short Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
title_sort deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209473/
https://www.ncbi.nlm.nih.gov/pubmed/35725730
http://dx.doi.org/10.1038/s41531-022-00343-6
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