Inhibition of BAD-Ser99 phosphorylation synergizes with PARP inhibition to ablate PTEN-deficient endometrial carcinoma

Loss of phosphatase and tensin homolog (PTEN) impairs DNA double-strand repair and confers sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis). However, PARPis also hyperactivate the MAPK and PI3K/AKT/mTOR pathways in PTEN-deficient endometrial carcinoma (EC), which allows the emergence...

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Detalles Bibliográficos
Autores principales: Zhang, Xi, Huang, Peng, Wang, Liqiong, Chen, Shu, Basappa, Basappa, Zhu, Tao, Lobie, Peter E., Pandey, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209517/
https://www.ncbi.nlm.nih.gov/pubmed/35725817
http://dx.doi.org/10.1038/s41419-022-04982-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209517/
https://www.ncbi.nlm.nih.gov/pubmed/35725817
http://dx.doi.org/10.1038/s41419-022-04982-8

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