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Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells
Heterochromatin maintains genome integrity and function, and is organised into distinct nuclear domains. Some of these domains are proposed to form by phase separation through the accumulation of HP1ɑ. Mouse heterochromatin contains noncoding major satellite repeats (MSR), which are highly transcrib...
Autores principales: | Novo, Clara Lopes, Wong, Emily V., Hockings, Colin, Poudel, Chetan, Sheekey, Eleanor, Wiese, Meike, Okkenhaug, Hanneke, Boulton, Simon J., Basu, Srinjan, Walker, Simon, Kaminski Schierle, Gabriele S., Narlikar, Geeta J., Rugg-Gunn, Peter J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209518/ https://www.ncbi.nlm.nih.gov/pubmed/35725842 http://dx.doi.org/10.1038/s41467-022-31198-3 |
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