Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers

Protein kinases play central roles in cellular regulation by catalyzing the phosphorylation of target proteins. Kinases have inherent structural flexibility allowing them to switch between active and inactive states. Quantitative characterization of kinase conformational dynamics is challenging. Her...

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Detalles Bibliográficos
Autores principales: Li, Fanjun, Fahie, Monifa A., Gilliam, Kaitlyn M., Pham, Ryan, Chen, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209526/
https://www.ncbi.nlm.nih.gov/pubmed/35725977
http://dx.doi.org/10.1038/s41467-022-31215-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209526/
https://www.ncbi.nlm.nih.gov/pubmed/35725977
http://dx.doi.org/10.1038/s41467-022-31215-5

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