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Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers
Protein kinases play central roles in cellular regulation by catalyzing the phosphorylation of target proteins. Kinases have inherent structural flexibility allowing them to switch between active and inactive states. Quantitative characterization of kinase conformational dynamics is challenging. Her...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209526/ https://www.ncbi.nlm.nih.gov/pubmed/35725977 http://dx.doi.org/10.1038/s41467-022-31215-5 |