Cariporide Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation and Apoptosis Partly Through Regulation of Akt/GSK-3β and Sirt1 Signaling Pathway

Background: Doxorubicin (DOX) is a potent chemotherapeutic agent with limited usage due to its cumulative cardiotoxicity. The Na(+)/H(+) exchanger isoform 1 (NHE1) is a known regulator of oxidative stress, inflammation, and apoptosis. The present study was designed to investigate the possible protec...

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Detalles Bibliográficos
Autores principales: Liao, Wenli, Rao, Zhiwei, Wu, Lingling, Chen, Yong, Li, Cairong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209753/
https://www.ncbi.nlm.nih.gov/pubmed/35747748
http://dx.doi.org/10.3389/fphar.2022.850053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209753/
https://www.ncbi.nlm.nih.gov/pubmed/35747748
http://dx.doi.org/10.3389/fphar.2022.850053

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