Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis

BACKGROUND: Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc). However, the role of calpain in interstitial lung disease (ILD) has no...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Zheng, Dong, Yan, Yuemei, Yu, Yong, Chen, Ruizhen, Li, Zheng, Greer, Peter A., Peng, Tianqing, Wang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210712/
https://www.ncbi.nlm.nih.gov/pubmed/35729674
http://dx.doi.org/10.1186/s13075-022-02833-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210712/
https://www.ncbi.nlm.nih.gov/pubmed/35729674
http://dx.doi.org/10.1186/s13075-022-02833-7

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