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Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure

OBJECTIVE: The monocyte–macrophage system is central to the host’s innate immune defense and in resolving injury. It is reported to be dysfunctional in acute-on-chronic liver failure (ACLF). The disease-associated alterations in ACLF monocytes are not fully understood. We investigated the mechanism...

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Detalles Bibliográficos
Autores principales: Maheshwari, Deepanshu, Kumar, Dhananjay, Jagdish, Rakesh Kumar, Nautiyal, Nidhi, Hidam, Ashinikumar, Kumari, Rekha, Sehgal, Rashi, Trehanpati, Nirupama, Baweja, Sukriti, Kumar, Guresh, Sinha, Swati, Bajpai, Meenu, Pamecha, Viniyendra, Bihari, Chhagan, Maiwall, Rakhi, Sarin, Shiv Kumar, Kumar, Anupam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210982/
https://www.ncbi.nlm.nih.gov/pubmed/35747140
http://dx.doi.org/10.3389/fimmu.2022.856587