The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study

Ritonavir-boosted darunavir (DRV/r) and dolutegravir (DTG) are affected by induction of metabolizing enzymes and efflux transporters caused by rifampicin (RIF). This complicates the treatment of people living with HIV (PLWH) diagnosed with tuberculosis. Recent data showed that doubling DRV/r dose di...

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Detalles Bibliográficos
Autores principales: De Nicolò, Amedeo, Calcagno, Andrea, Motta, Ilaria, De Vivo, Elisa, D’Avolio, Antonio, Di Perri, Giovanni, Wiesner, Lubbe, Ebrahim, Isma-eel, Maartens, Gary, Orrell, Catherine, McIlleron, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211429/
https://www.ncbi.nlm.nih.gov/pubmed/35583344
http://dx.doi.org/10.1128/aac.00136-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211429/
https://www.ncbi.nlm.nih.gov/pubmed/35583344
http://dx.doi.org/10.1128/aac.00136-22

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