A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations

The shelterin protein POT1 has been found mutated in many different familial and sporadic cancers, however, no mouse models to understand the pathobiology of these mutations have been developed so far. To address the molecular mechanisms underlying the tumorigenic effects of POT1 mutant proteins in...

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Detalles Bibliográficos
Autores principales: Martínez, Paula, Sánchez-Vázquez, Raúl, Ferrara-Romeo, Iole, Serrano, Rosa, Flores, Juana M., Blasco, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212151/
https://www.ncbi.nlm.nih.gov/pubmed/35727838
http://dx.doi.org/10.1371/journal.pgen.1010260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212151/
https://www.ncbi.nlm.nih.gov/pubmed/35727838
http://dx.doi.org/10.1371/journal.pgen.1010260

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