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An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

Surface-associated, coiled-coil M proteins of Streptococcus pyogenes (Strep A) disable human immunity through interaction with select proteins. However, coiled coils lack features typical of protein–protein interaction sites, and it is therefore challenging to understand how M proteins achieve speci...

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Detalles Bibliográficos
Autores principales: Kolesinski, Piotr, Wang, Kuei-Chen, Hirose, Yujiro, Nizet, Victor, Ghosh, Partho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212996/
https://www.ncbi.nlm.nih.gov/pubmed/35726694
http://dx.doi.org/10.7554/eLife.77989