A CRISPRi mediated self-inducible system for dynamic regulation of TCA cycle and improvement of itaconic acid production in Escherichia coli

Itaconic acid (ITA), an effective alternative fossil fuel, derives from the bypass pathway of the tricarboxylic acid (TCA) cycle. Therefore, the imbalance of metabolic flux between TCA cycle and ITA biosynthetic pathway seriously limits the production of ITA. The optimization of flux distribution be...

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Detalles Bibliográficos
Autores principales: Zhao, Ming, Li, Yuting, Wang, Fengqing, Ren, Yuhong, Wei, Dongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213231/
https://www.ncbi.nlm.nih.gov/pubmed/35782485
http://dx.doi.org/10.1016/j.synbio.2022.05.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213231/
https://www.ncbi.nlm.nih.gov/pubmed/35782485
http://dx.doi.org/10.1016/j.synbio.2022.05.008

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