A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome

CARD8 is a pattern-recognition receptor that forms a caspase-1-activating inflammasome. CARD8 undergoes constitutive autoproteolysis, generating an N-terminal (NT) fragment with a disordered region and a ZU5 domain and a C-terminal (CT) fragment with UPA and CARD domains. Dipeptidyl peptidase 8 and...

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Detalles Bibliográficos
Autores principales: Hsiao, Jeffrey C., Neugroschl, Atara R., Chui, Ashley J., Taabazuing, Cornelius Y., Griswold, Andrew R., Wang, Qinghui, Huang, Hsin-Che, Orth-He, Elizabeth L., Ball, Daniel P., Hiotis, Giorgos, Bachovchin, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213247/
https://www.ncbi.nlm.nih.gov/pubmed/35580636
http://dx.doi.org/10.1016/j.jbc.2022.102032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213247/
https://www.ncbi.nlm.nih.gov/pubmed/35580636
http://dx.doi.org/10.1016/j.jbc.2022.102032

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