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NMDA receptor inhibition prevents intracellular sodium elevations in human olfactory neuroepithelial precursors derived from bipolar patients

Dysregulation of ion flux across membranes and glutamate-induced excitotoxicity appear to be important pathophysiologic abnormalities in bipolar illness. Understanding ion control and responses to ionic stress is important to decipher the pathogenesis of this disorder. Monensin alone significantly i...

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Detalles Bibliográficos
Autores principales: Gao, Yonglin, Mack, Aaron A., Litteral, Carleigh, Delamere, Nicholas A., El-Mallakh, Rif S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213398/
https://www.ncbi.nlm.nih.gov/pubmed/35729322
http://dx.doi.org/10.1038/s41598-022-14187-w