3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity

As there is a continuous need for novel anti-infectives, the present study aimed to fuse two modes of action into a novel 3-nitroimidazo[1,2-b]pyridazine scaffold to improve antiparasitic efficacy. For this purpose, we combined known structural elements of phosphodiesterase inhibitors, a target rece...

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Detalles Bibliográficos
Autores principales: Zheng, Yang, Müller, Joachim, Kunz, Stefan, Siderius, Marco, Maes, Louis, Caljon, Guy, Müller, Norbert, Hemphill, Andrew, Sterk, Geert Jan, Leurs, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213561/
https://www.ncbi.nlm.nih.gov/pubmed/35716585
http://dx.doi.org/10.1016/j.ijpddr.2022.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213561/
https://www.ncbi.nlm.nih.gov/pubmed/35716585
http://dx.doi.org/10.1016/j.ijpddr.2022.05.004

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