Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice

Elderly patients with traumatic brain injury (TBI) have greater mortality and poorer outcomes than younger individuals. The extent to which old age alters long-term recovery and chronic microglial activation after TBI is unknown, and evidence for therapeutic efficacy in aged mice is sorely lacking....

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Detalles Bibliográficos
Autores principales: Ritzel, Rodney M., Li, Yun, Lei, Zhuofan, Carter, Jordan, He, Junyun, Choi, Harry M. C., Khan, Niaz, Li, Hui, Allen, Samantha, Lipinski, Marta M., Faden, Alan I., Wu, Junfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213636/
https://www.ncbi.nlm.nih.gov/pubmed/35451674
http://dx.doi.org/10.1007/s11357-022-00562-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213636/
https://www.ncbi.nlm.nih.gov/pubmed/35451674
http://dx.doi.org/10.1007/s11357-022-00562-y

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