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DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes
OBJECTIVE: Type 1 Diabetes (T1D) is characterized by progressive loss of insulin-producing pancreatic β cells as a result of autoimmune destruction. In addition to β cell death, recent work has shown that subpopulations of β cells acquire dysfunction during T1D. We previously reported that β cells u...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213768/ https://www.ncbi.nlm.nih.gov/pubmed/35660116 http://dx.doi.org/10.1016/j.molmet.2022.101524 |