Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the trop...

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Detalles Bibliográficos
Autores principales: Mahmud, Zabed, Tikunova, Svetlana, Belevych, Natalya, Wagg, Cory S., Zhabyeyev, Pavel, Liu, Philip B., Rasicci, David V., Yengo, Christopher M., Oudit, Gavin Y., Lopaschuk, Gary D., Reiser, Peter J., Davis, Jonathan P., Hwang, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213791/
https://www.ncbi.nlm.nih.gov/pubmed/35755445
http://dx.doi.org/10.3389/fphys.2022.892979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213791/
https://www.ncbi.nlm.nih.gov/pubmed/35755445
http://dx.doi.org/10.3389/fphys.2022.892979

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