Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism

The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes. Progestin and adipoQ receptor 3 (PAQR3), a key regulator of inflammation and metabolism, can negatively regulate the PI3K/AKT signaling pathway. Here, we report that gentiopicroside (GPS), the mai...

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Detalles Bibliográficos
Autores principales: Xiao, Haiming, Sun, Xiaohong, Lin, Zeyuan, Yang, Yan, Zhang, Meng, Xu, Zhanchi, Liu, Peiqing, Liu, Zhongqiu, Huang, Heqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214054/
https://www.ncbi.nlm.nih.gov/pubmed/35755276
http://dx.doi.org/10.1016/j.apsb.2021.12.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214054/
https://www.ncbi.nlm.nih.gov/pubmed/35755276
http://dx.doi.org/10.1016/j.apsb.2021.12.023

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