A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization

Glioma is a primary aggressive brain tumor with high recurrence rate. The poor efficiency of chemotherapeutic drugs crossing the blood‒brain barrier (BBB) is well-known as one of the main challenges for anti-glioma therapy. Moreover, massive infiltrated tumor-associated macrophages (TAMs) in glioma...

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Detalles Bibliográficos
Autores principales: Yang, Tingting, Hu, Yuzhu, Miao, Junming, Chen, Jing, Liu, Jiagang, Cheng, Yongzhong, Gao, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214068/
https://www.ncbi.nlm.nih.gov/pubmed/35755286
http://dx.doi.org/10.1016/j.apsb.2022.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214068/
https://www.ncbi.nlm.nih.gov/pubmed/35755286
http://dx.doi.org/10.1016/j.apsb.2022.02.009

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