Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity t...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Peilu, Zhao, Fan, Li, Dahong, Qu, Jiqiang, Yao, Miao, Su, Yuan, Wang, Hanxun, Zhou, Miaomiao, Wang, Yujie, Gao, Yinli, Li, Feng, Zhao, Dongmei, Zhang, Fengjiao, Rao, Yu, Xia, Mingyu, Li, Haitao, Wang, Jian, Cheng, Maosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214071/
https://www.ncbi.nlm.nih.gov/pubmed/35755272
http://dx.doi.org/10.1016/j.apsb.2022.02.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214071/
https://www.ncbi.nlm.nih.gov/pubmed/35755272
http://dx.doi.org/10.1016/j.apsb.2022.02.029

Ejemplares similares